481 Exploring the molecular discordance between primary and metastatic melanoma
نویسندگان
چکیده
منابع مشابه
Comparison of c-Kit expression between primary and metastatic melanoma of skin and mucosa
Background: Melanoma causes the greatest morbidity and mortality of all skin cancers. Mucosal melanoma is a rare but highly aggressive neoplasm. According to previous studies the prevalence of KIT mutations in acrallentiginous and mucosal melanomas is relatively low (less than 15–20%), but it can have profound therapeutic implications for localized high risk or metastatic diseases. Our goal w...
متن کاملexploring the relationship between iranian efl learners multiple intelligences, locus of control and reading proficiency
12 چکیده تفاوت های فردی، به عنوان خصوصیات روانشناختی غالب، باید در سطوح مختلف تدریس و یادگیری زبان کاملاً مورد ملاحظه قرار گیرند. از میان تاثیرگذارترین سازه های روانشناختی که منجر به تفاوت های فردی می شوند، می توان ازهوش چندگانه و منبع کنترل نام برد. هوش چندگانه با جنبه های متفاوتی از هوش سر و کار دارد که ممکن است هر شخص از آن برخوردار باشد. منبع کنترل، به عنوان مفهوم روانشناختی دیگر، به استن...
15 صفحه اولThe significance of BRAF V600E mutation status discordance between primary cutaneous melanoma and brain metastases
To compare BRAF V600E status of primarymelanoma and brainmetastases to assess for discordance by cross-sectional study, and to evaluate clinical implications on BRAF inhibitor therapy. Brain metastases are common in patients with advanced melanoma. Between 40% and 60% of melanomas demonstrate BRAF mutations, BRAF V600E being most common. Selective BRAF inhibitor therapy has shown improvement in...
متن کاملcomparison of c-kit expression between primary and metastatic melanoma of skin and mucosa
background: melanoma causes the greatest morbidity and mortality of all skin cancers. mucosal melanoma is a rare but highly aggressive neoplasm. according to previous studies the prevalence of kit mutations in acrallentiginous and mucosal melanomas is relatively low (less than 15–20%), but it can have profound therapeutic implications for localized high risk or metastatic diseases. our goal was...
متن کاملTumor Homogeneity between Primary and Metastatic Sites for BRAF Status in Metastatic Melanoma Determined by Immunohistochemical and Molecular Testing
BRAF inhibitors have demonstrated improvement of overall survival in patients with metastatic melanoma and BRAF(V600) mutations. In order to evaluate BRAF tumor heterogeneity between primary and metastatic site, we have evaluated the performance of immunohistochemistry (IHC) with an anti-BRAF(V600E) antibody in both localization by comparison with high resolution melting analysis followed by Sa...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2019
ISSN: 0022-202X
DOI: 10.1016/j.jid.2019.07.531